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On December 11, the Laboratory of Structural Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article in Science Advances titled “Cryo-EM Structure of Nipah Virus RNA Polymerase Complex.” This study provides a detailed characterization of the structural features of the Nipah virus polymerase complex.

​Recently, the Laboratory of Structural Biochemistry at SIAIS, led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article entitled “Class I histone deacetylase complex: structure and functional correlates” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a 3.2 Å resolution cryo-EM structure of the class I histone deacetylase (HDAC) complex.

​Recently, a group led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao of the laboratory of structure biochemistry at SIAIS, published a paper entitled “Structure of the NuA4 histone acetyltransferase complex” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a near-atomic resolution structure of the NuA4 complex in eukaryotes obtained by cryo-electron microscopy (cryo-EM).

Assistant Professor Liu Jia’s group at SIAIS along with his collaborator, Professor Qu Jieming at Ruijin Hospital designed a novel surfaceome CRISPR library and identified OLFML3 as a novel host factor of rhinovirus (RV).